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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
CDK12
All Species:
19.39
Human Site:
S1386
Identified Species:
47.41
UniProt:
Q9NYV4
Number Species:
9
Phosphosite Substitution
Charge Score:
-0.11
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9NYV4
NP_055898.1
1490
164155
S1386
S
L
S
H
L
G
E
S
S
S
Y
Q
G
T
G
Chimpanzee
Pan troglodytes
XP_001139939
1512
164915
S1397
P
P
Q
P
S
A
F
S
E
S
F
P
S
S
V
Rhesus Macaque
Macaca mulatta
XP_001088594
1490
164086
S1386
S
V
S
H
L
G
E
S
S
S
Y
Q
G
T
G
Dog
Lupus familis
XP_548147
1490
164467
S1386
S
V
S
H
L
G
E
S
S
S
Y
Q
G
T
G
Cat
Felis silvestris
Mouse
Mus musculus
Q14AX6
1484
163663
S1382
S
V
S
H
L
G
E
S
N
S
Y
Q
G
T
G
Rat
Rattus norvegicus
Q3MJK5
1484
163772
S1382
S
V
S
H
L
G
E
S
N
S
Y
Q
G
T
G
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
XP_687417
1286
141523
R1200
G
Y
G
G
D
F
G
R
P
P
P
P
F
P
H
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
XP_397595
1492
167042
G1393
A
A
N
S
R
S
S
G
L
I
E
S
Q
L
P
Nematode Worm
Caenorhab. elegans
P46551
730
82410
G644
R
L
G
R
Q
A
E
G
S
S
G
S
G
H
S
Sea Urchin
Strong. purpuratus
XP_789337
1264
139419
P1178
N
L
P
Q
P
P
E
P
S
L
P
P
P
D
N
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
42.3
98.4
95.1
N.A.
91.1
91.7
N.A.
N.A.
N.A.
N.A.
39.1
N.A.
N.A.
36
27.6
35.7
Protein Similarity:
100
54.2
99.1
96.9
N.A.
94.7
95
N.A.
N.A.
N.A.
N.A.
50.4
N.A.
N.A.
51.7
36
49.5
P-Site Identity:
100
13.3
93.3
93.3
N.A.
86.6
86.6
N.A.
N.A.
N.A.
N.A.
0
N.A.
N.A.
0
33.3
20
P-Site Similarity:
100
26.6
100
100
N.A.
100
100
N.A.
N.A.
N.A.
N.A.
0
N.A.
N.A.
13.3
33.3
26.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
10
10
0
0
0
20
0
0
0
0
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
10
0
0
0
0
0
0
0
0
10
0
% D
% Glu:
0
0
0
0
0
0
70
0
10
0
10
0
0
0
0
% E
% Phe:
0
0
0
0
0
10
10
0
0
0
10
0
10
0
0
% F
% Gly:
10
0
20
10
0
50
10
20
0
0
10
0
60
0
50
% G
% His:
0
0
0
50
0
0
0
0
0
0
0
0
0
10
10
% H
% Ile:
0
0
0
0
0
0
0
0
0
10
0
0
0
0
0
% I
% Lys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% K
% Leu:
0
30
0
0
50
0
0
0
10
10
0
0
0
10
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
10
0
10
0
0
0
0
0
20
0
0
0
0
0
10
% N
% Pro:
10
10
10
10
10
10
0
10
10
10
20
30
10
10
10
% P
% Gln:
0
0
10
10
10
0
0
0
0
0
0
50
10
0
0
% Q
% Arg:
10
0
0
10
10
0
0
10
0
0
0
0
0
0
0
% R
% Ser:
50
0
50
10
10
10
10
60
50
70
0
20
10
10
10
% S
% Thr:
0
0
0
0
0
0
0
0
0
0
0
0
0
50
0
% T
% Val:
0
40
0
0
0
0
0
0
0
0
0
0
0
0
10
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
10
0
0
0
0
0
0
0
0
50
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _